| Home | Free Articles for Your Site | Submit an Article | Advertise | Link to Us | Search | Contact Us |
This site is an archive of old articles

    SEARCH ARTICLES
    Custom Search


vertical line

Article Surfing Archive



Is Oxidative Stress Affecting Your Dna? - Articles Surfing

Many people today are becoming more aware of using antioxidants (from specific foods or supplements) to combat oxidative stress. When asked why antioxidant strategies are taken, many say they fear oxidative damage to their DNA (deoxyribonucleic acid), a molecule containing genetic instructions for building cells.

These fears may be justified. The fact is, the resulting mutation from oxidized DNA may trigger pathological outcomes, including cancer, neurological degeneration and organ failure. Other oxidation targets include proteins, cell membranes, lysosomes, mitochondria, blood and tissue lipids, polyunsaturated fatty acids, and vitamins or antioxidant molecules themselves. So, how does oxidative stress begin and what attacks the DNA?

Oxidative Stress on our DNA

Our bodies use oxygen to create energy as fuel for our cells, forming by-products in the process. Carbon dioxide and water are two such by-products, but others include reactive oxygen species (ROS), which have both beneficial and potentially dangerous roles in human physiology.

ROS are reactive species because they lack an electron. This electron deficiency then forces the reactive species to aggressively seek a new one from any source, including cell membranes and DNA. Usually, the ROS are neutralized by antioxidants our bodies form (endogenous antioxidants, e.g., glutathione) and by antioxidants provided from food (dietary antioxidants, e.g., phenolics).

Reactive Oxygen Species'the good side, the bad side

The beneficial roles of ROS include antibacterial and antiviral actions, cell-to-cell signaling (such as by nitric oxide and hydrogen peroxide), stimulation of enzyme functions, and regulation of cells controlling release of hormones. That's the good. However, when your body produces more ROS than needed to perform these useful functions, and when you body doesn't have enough antioxidant reserves, this creates a positive-ROS state, or oxidative stress.

How to possibly prevent an oxidative attack

Even during healthy and normal metabolism ' but worsened by exposure to added environmental pathogens such as ultraviolet radiation, smoke or other pollutants ' the ROS (which are formed continuously) are attacking each cell in our bodies thousands of times per minute or more than a million times per day!

When counterbalancing antioxidant mechanisms are insufficient, DNA lesions occur, including loss or oxidation of base material and breaks of DNA strands. The good news is that not all DNA lesions become pathogenic, as our cells (hard-workers, indeed) also contain mending functions for correcting the DNA injury, called base excision repair (BER).

While it works to repair most of the time, BER may not fully correct all injuries to DNA, leading to mutated DNA, as found in carcinogenesis, aging or age-related diseases.

Give your body a "metabolic tune-up"

For 20 years, Dr. Bruce N. Ames of the University of California-Berkeley has analyzed ROS-initiated DNA lesions, aging onset and disease progression, and has advocated nutritional remedies as protection, including dietary supplementation with lipoic acid, acetylcarnitine, folic acid, biotin, vitamins C, E, B6 (pyridoxine) and -12 (cyanocobalamin), iron and zinc. Together, these nutrients provide what Dr. Ames has coined a 'metabolic tune-up.'

An excerpt from a 2002 publication in the Annals of the NY Academy of Science (partly edited)

In feeding studies in old rats, these mitochondrial metabolites and antioxidants furnish several benefits that include :
1) arresting the age-associated decline of ambulatory activity and memory,
2) partially restoring mitochondrial structure and function,
3) inhibiting age-associated increase of oxidative damage to lipids, proteins, and nucleic acids,
4) elevating levels of antioxidants,
5) restoring activity and substrate binding affinity of a key mitochondrial enzyme, carnitine acetyltransferase.

These mitochondrial metabolites and antioxidants:
1) protect neuronal cells from neurotoxin- and oxidant-induced toxicity and oxidative damage;
2) delay the normal aging of human fibroblast cells,
3) inhibit oxidant-induced acceleration of aging.

These results suggest a plausible mechanism: with age, increased oxidative damage to proteins and lipid membranes, particularly in mitochondria, causes a) a deformation of enzyme structure, with b) a consequent decrease of enzyme activity as well as c) substrate binding affinity for their substrates. An increased level of substrate restores the velocity of the reaction and restores mitochondrial function, thus delaying mitochondrial decay and aging.

So, if you want fight reactive oxygen radicals, eat the right antioxidant foods.

References and Reading

* Liu J, Atamna H, Kuratsune H, Ames BN. Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann N Y Acad Sci. 2002 Apr;959:133-66.
* Ames BN. A role for supplements in optimizing health: the metabolic tune-up. Arch Biochem Biophys. 2004 Mar 1;423(1):227-34.
* PubMed, online database of the US National Library of Medicine, http://pubmed.org
* Wikipedia, the free encyclopedia, Oxidative Stress, http://en.wikipedia.org/wiki/Oxidative_stress

Reading and References
* Nutrient Data Laboratory, Agricultural Research Service, US Department of Agriculture, http://www.nal.usda.gov/fnic/foodcomp/contact.html
* Phytochemical database of the USDA, Agricultural Research Service, http://www.pl.barc.usda.gov/usda_chem/achem_home.cfm
* Wikipedia, the free encyclopedia, http://www.wikipedia.com

Copyright 2006 Berry Health Inc.

Submitted by:

Dr. Paul Gross

Dr. Paul Gross is a scientist and expert on cardiovascular and brain physiology. Gross is founder of Berry Health Inc, a developer of nutritional, berry-based supplements. For more information, visit http://www.berrywiseonline.com



        RELATED SITES






https://articlesurfing.org/wellness_fitness_and_diet/is_oxidative_stress_affecting_your_dna.html

Copyright © 1995 - Photius Coutsoukis (All Rights Reserved).










ARTICLE CATEGORIES

Aging
Arts and Crafts
Auto and Trucks
Automotive
Business
Business and Finance
Cancer Survival
Career
Classifieds
Computers and Internet
Computers and Technology
Cooking
Culture
Education
Education #2
Entertainment
Etiquette
Family
Finances
Food and Drink
Food and Drink B
Gadgets and Gizmos
Gardening
Health
Hobbies
Home Improvement
Home Management
Humor
Internet
Jobs
Kids and Teens
Learning Languages
Leadership
Legal
Legal B
Marketing
Marketing B
Medical Business
Medicines and Remedies
Music and Movies
Online Business
Opinions
Parenting
Parenting B
Pets
Pets and Animals
Poetry
Politics
Politics and Government
Real Estate
Recreation
Recreation and Sports
Science
Self Help
Self Improvement
Short Stories
Site Promotion
Society
Sports
Travel and Leisure
Travel Part B
Web Development
Wellness, Fitness and Diet
World Affairs
Writing
Writing B